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Insulin Resistance – Source of Most Chronic Disease

Insulin Resistance – Source of Most Chronic Disease

One of the significant threats to global health in the 21st century is insulin resistance, which is the key factor in the development of type 2 diabetes, cardiovascular disease, fatty liver disease, neurogenerative disease, and obesity-associated cancers.
Understanding the molecular basis for insulin resistance leads to specific therapy that helps prevent this common disorder, and we now have a medicine that cleans up the mess in the vascular system after years and even decades of our bodies’ being under the sway of insulin resistance.

Insulin resistance (IR) is associated with an impaired biological response to insulin stimulation of key target tissues, particularly liver, muscle, and adipose tissue. IR impacts glucose utilization, resulting in a compensatory increase in beta-cell insulin production and hyperinsulinemia.

| Source: Dr. Sircus.com

The hormone insulin, produced by the pancreas, regulates blood glucose, or sugar from our food, by allowing it to enter the body’s cells, which are used for energy. Insulin resistance—found in lean and overweight individuals—occurs when the body’s cells don’t effectively respond to insulin and take in glucose, leading to high blood sugar levels. Insulin resistance (IR) is the subnormal response to insulin action on target tissues. Studies suggest that IR increases the risk of hypertension.

Dr. Benjamin Bikman says, “We know that insulin resistance is at the core of most chronic diseases that are killing us. Insulin is a hormone that literally affects every cell of the body. But if those cells become insulin-resistant, you start to spread disease. 88 % of adults in the United States have some insulin resistance.” He also says, “Stress hormones will create insulin resistance pretty quickly. Sleep disturbances as well, and, of course, inflammation will cause insulin resistance. Few understand that high levels of insulin will also cause insulin resistance.”

Low serum and intracellular magnesium concentrations are associated with insulin resistance, impaired glucose tolerance, and decreased insulin secretion. 

Magnesium improves insulin sensitivity, thus lowering insulin resistance. Magnesium and insulin need each other.

What causes high insulin levels that will create insulin resistance? Stress, insomnia, and inflammation can be fast causes of insulin resistance and can often be resolved quickly. But the slow, insidious cause is overeating, especially if on a high-carbohydrate diet, which most people are. In conjunction with eating too many times a day, this does not allow insulin levels to drop. The cells get tired of all the insulin and start resisting.

Eating too much and too frequently is deadly in the end. With so many overweight and obese people, we can see why health is in the trash for so many Americans.

Dr. Luc Tappy says, “The equivalent of the fructose in 8-10 cans of
Coke or Pepsi a day—is a pretty high dose, leaving people to become
insulin-resistant, and triglyceride increases in just a few days.[i]

The term insulin resistance encompasses a broad continuum, ranging from individuals who maintain normal glucose homeostasis due to increased endogenous insulin production and do not yet have diabetes to individuals with diabetes who require exogenous insulin to maintain glucose homeostasis. 

Insulin, especially at high concentrations, can accelerate the atherosclerotic process by multiple mechanisms, including increased LDL synthesis/secretion, vascular smooth muscle cell growth and proliferation, activation of genes involved in inflammation, increased collagen synthesis, and enhanced LDL cholesterol transport into arterial smooth muscle cells.[ii]

Dr. Ron Rosedale says, “Insulin floating around in the blood causes plaque build-up. They didn’t know why until recently, but Insulin causes endothelial proliferation. Every step of the way, Insulin causes cardiovascular disease. It fills the body with plaque. It constricts the arteries. It stimulates the sympathetic nervous system, increasing platelet adhesiveness and coagulability of the blood.”

    The heart suffers from dangerous nutritional deficiencies,
    including a lack of sun and Vitamin D, magnesium, and iodine.

    Multiple studies have demonstrated that insulin resistance strongly predicts atherosclerotic cardiovascular (CV) disease. Insulin resistance is associated with atherosclerosis, meaning Hyperinsulinemia accelerates the development of atherosclerosis. Insulin resistance raises blood sugar levels, and high blood sugar leads to inflammation, which damages the lining inside arteries. The suggestion that insulin is associated with atherosclerosis is based on clinical, epidemiologic, and experimental evidence.

    Coronary, cerebral, and peripheral artery atherosclerosis is associated with abnormally high insulin responses to oral glucose. Dr. Elliott Joslin noted that insulin has necessary indirect actions on the vascular system through its regulation of lipids and the development of hardening of the arteries.

    Atherosclerosis, the underlying cause of heart disease and other vascular disorders, is characterized by endothelial dysfunction and a limited capacity to produce nitric oxide. It is a vicious cycle. Diseased arteries cannot generate enough protective nitric oxide, and low nitric oxide levels set the stage for further damage, hypertension, and increased risk of cardiac events.

    This explains why nitroglycerin is such an effective therapy for angina. It triggers nitric oxide production, which dilates narrowed coronary arteries, improving circulation and delivering much-needed oxygen to the heart muscle.

    Metabolic syndrome can also be known as insulin resistance syndrome (IRS) because the underlying insulin resistance is the etiologic factor responsible for developing cardiometabolic disturbances. Insulin resistance characterizes type 2 diabetes and metabolic syndrome, disorders associated with an increased risk of death due to macrovascular disease.

    According to a 2024 national survey, 70% of Americans are unaware of peripheral artery disease (PAD) – the most common vascular disease in which leg arteries become narrowed, reducing or cutting off blood flow, contributing to 400 amputations performed each day in the United States. This all starts with insulin resistance.

    Many people with blocked arteries or atherosclerosis are unaware that they have it until they develop symptoms such as angina or claudication. Claudication is a medical term usually referring to impairment in walking or pain, discomfort, numbness, or tiredness in the legs that occurs during walking or standing and is relieved by rest. Unfortunately, the first time that someone realizes that they have atherosclerosis is only when they have an event such as a stroke or a heart attack.

    Cardiovascular disease is a leading cause of morbidity and mortality worldwide and significantly affects the quality of life of hundreds of millions of people. Atherosclerosis causes 4 of 10 deaths, with drug treatment limited to incremental advances in lipoprotein management. Modern medicine is not particularly savvy when it comes to arterial disease.

    High glucose levels are dangerous for the arteries. Roughly one in four Americans with diabetes is unaware that they have the disease. Thus, untreated diabetes increases glucose, or sugar, in the blood, damaging the inner linings of both big and small arteries. The arteries respond by layering on plaque, a substance that fills the arteries so that oxygen-rich blood has difficulty getting through to the eyes, kidneys, legs, and feet. Sugar is an arterial poison. So is stress.

    Treating the Long-term Effects of Insulin Resistance

    Now comes the recent discovery of a new wonder drug that safely strips cholesterol out of vascular plaque. This means we now have access to cyclodextrins, the Ultimate Vascular Medicine, which are safer and more effective than statin drugs. Instead of using statins to control cholesterol levels chemically, with side effects including increased incidence of diabetes and cancer, with cyclodextrins, we reduce obstructions all over the vascular system and even beyond into the organs. 

    Cyclodextrins administered intravenously or rectally are the way to reverse decades of plaque buildup quickly.

    Recent research suggests Cyclodextrins may play a role in metabolic disorders, including insulin resistance, by influencing cholesterol metabolism, lipid accumulation, and inflammation—all of which are key factors in insulin resistance and type 2 diabetes. Cyclodextrins promise to improve insulin sensitivity by reducing cholesterol buildup, inflammation, and lipid accumulation. Thus, Type 2 Diabetics should use cyclodextrins to improve glucose control in insulin-resistant individuals.

    How Cyclodextrins May Affect Insulin Resistance

    1. Cholesterol and Lipid Metabolism
      • Insulin resistance is strongly linked to lipid accumulation and cholesterol imbalances, particularly in the liver and muscle.
      • HPβCD (2-hydroxypropyl-β-cyclodextrin) has been shown to enhance cholesterol efflux from cells, preventing lipid buildup that impairs insulin signaling.
      • Studies in obese and diabetic mice have shown that HPβCD reduces liver fat accumulation, improving insulin sensitivity.
    2. Reduction of Inflammation
      • Chronic low-grade inflammation is a major driver of insulin resistance.
      • Cyclodextrins, particularly HPβCD, have been found to reduce pro-inflammatory cytokines (TNF-α, IL-6), leading to improved insulin signaling.
      • By clearing cholesterol from macrophages (immune cells), cyclodextrins may help prevent the inflammatory response that disrupts glucose metabolism.
    3. Fatty Acid and Adipose Tissue Regulation
      • Insulin resistance is linked to excessive visceral fat and dysregulated fatty acid metabolism.
      • Some studies indicate that cyclodextrins may help modulate adipocyte (fat cell) function, preventing lipid-induced insulin resistance.
      • By reducing ectopic fat deposition in skeletal muscle and liver, CDs may help restore normal insulin function.

    Treating The Main Cause of Insulin Resistance

    Magnesium participates directly in glucose metabolism disorders in humans.[iii] There is an essential connection between insulin resistance and magnesium. The incidence of insulin resistance and metabolic syndrome correlates with magnesium (Mg) availability.[iv] 

    Magnesium is a vital mineral involved in over 300 enzymatic reactions, including those regulating glucose metabolism and insulin sensitivity. Research suggests that low magnesium levels are associated with an increased risk of insulin resistance, type 2 diabetes, and metabolic syndrome.

    Below is just a summary. Much of Natural Cardiology is dedicated to magnesium for treating cardiovascular disease. It is an essential medicine (not just a supplement) that needs to be first in every treatment protocol. If one wants to avoid a stroke or cardiac arrest, it is best to take these words seriously, or your family might find you one day suddenly dead or incapacitated with a stroke. The strangest aspect of modern medicine and its hordes of doctors is that they continue to ignore magnesium to the detriment of all their patients. If Kennedy wants to see a revival of American health, he should start a national magnesium program. Magnesium deficiency is the most basic epidemic in America.

    How Magnesium Influences Insulin Sensitivity

     

    1. Enhances Insulin Action
      • Magnesium is necessary for insulin receptor function. Without enough magnesium, insulin cannot effectively bind to its receptors, leading to insulin resistance.
    2. Regulates Blood Sugar Levels
      • Magnesium helps transport glucose into cells, which are used for energy. Low magnesium levels impair this process, contributing to higher blood sugar levels.
    3. Reduces Inflammation
      • Chronic inflammation is a key driver of insulin resistance. Magnesium has anti-inflammatory properties, helping to lower markers like C-reactive protein (CRP).
    4. Lowers Oxidative Stress
      • Magnesium acts as an antioxidant, protecting cells from oxidative stress, which is known to impair insulin signaling.
    5. Supports Mitochondrial Function
      • Mitochondria, the energy powerhouses of cells, require magnesium for ATP production. Healthy mitochondria improve glucose utilization and metabolic function.

    Magnesium Deficiency and Insulin Resistance

    • Studies have shown that people with type 2 diabetes and metabolic syndrome often have lower levels of magnesium.
    • Deficiency can be caused by:
      • Poor diet (low intake of magnesium-rich foods)
      • High sugar consumption (which increases magnesium excretion)
      • Chronic stress (which depletes magnesium)
      • Certain medications (e.g., diuretics, proton pump inhibitors)
      • Digestive disorders (like Crohn’s disease, which impairs absorption)

    Throughout Natural Cardiology, you will find information on magnesium. It is the ultimate heart medicine, while cyclodextrins are the ultimate vascular medicine. Combined, they hold the potential to vanquish much of the death and suffering of heart and vascular disease.

    [i] “Toxic” effects of sugar: should we be afraid of fructose?

    Luc Tappy; BMC Biology 2012, 10:42 http://www.biomedcentral.com/1741-7007/10/42

    [ii] Insulin Resistance and Atherosclerosis: Implications for Insulin-Sensitizing Agents

    Antonino Di Pino, Ralph A DeFronzo. Endocrine Reviews, Volume 40, Issue 6, December 2019, Pages 1447–1467, https://doi.org/10.1210/er.2018-00141

    [iii] Nutrition Volume 38, June 2017, Pages 54-60. Effect of magnesium supplementation on insulin resistance in humans: A systematic review

    [iv] Diabetes Obes Metab. 2011 Mar;13(3):281-4. Oral magnesium supplementation reduces insulin resistance in non-diabetic subjects – a double-blind, placebo-controlled, randomized trial

      List of Vitamins, Minerals and Food Sources

      List of Vitamins, Minerals and Food Sources

      List of Vitamins, Minerals and Food Sources: You are well aware of an overflow of information and you are probably screaming out inside because you are not a sponge that can absorb and absorb.

      We are humans, trying to figure out what is best for our families and their health matters a great deal. Some of us, well, we just give up and let others decide for us.

      Social media bombards us with the “next best thing” and you have cupboards full of unused vitamins and minerals with known brands and yet you and your family are exhausted, fatigued and frustrated.

      I’m writing this blog to make it easier to understand, as I was where you are now and for this reason, I felt I needed to share “simplicity” as we humans, make things so complicated when it should be easily understood like a child would.

      Absorption:

      As I mentioned above, we are taking handfuls of pills or capsules in the evenings, mornings and some even in the evenings. In the long run, we don’t know whether these vitamins and minerals are absorbing and that’s where a simple natural electrolyte mineral such as Fulvic Humic Acid comes in.

      Fulvic Humic Acid?

      Our all-natural formula is designed to provide essential nutrients, including minerals, vitamins, amino acids, and essential fatty acids. Additionally, it helps to boost absorption, increase energy, and protect against heavy metals. Whether you’re an athlete, outdoor enthusiast, or simply looking to maintain overall health, Fulvic Humic Acid Powder is suitable for you.

      Now, let’s get to the nitty gritty stuff of vitamins, minerals, and some foods that you can include.

      If you’re anything like me, you appreciate having a “quick list” of essentials. If you’re already familiar with the vital vitamins and minerals, simply scroll to the bottom to grab our quick reference chart, linking products with potential health benefits.

      But if you’re seeking to understand the fundamentals, regardless of your prior knowledge or anatomy background, Kathy is offering her 14 years of wisdom in an accessible and affordable format: the “Body Detox Online Course.” Trust me, it’s worth every bit of your time and investment.

      Here is a list of essential vitamins for the human body, along with the potential causes of deficiency:

      • Vitamin A: necessary for healthy vision, immune function, and cell growth. Deficiency can cause night blindness, dry skin, and increased susceptibility to infection.
      • Vitamin B1 (thiamine): helps the body convert food into energy. Deficiency can cause fatigue, irritability, and anorexia.
      • Vitamin B2 (riboflavin): helps the body convert food into energy, supports healthy skin, and aids in the production of red blood cells. Deficiency can cause sore throat, mouth sores, and anemia.
      • Vitamin B3 (niacin): helps the body convert food into energy, supports healthy skin and nerves. Deficiency can cause pellagra, a condition characterized by skin inflammation, diarrhoea, and dementia.
      • Vitamin B5 (pantothenic acid): helps the body convert food into energy and is important for healthy skin. Deficiency is rare but can cause fatigue and insomnia.
      • Vitamin B6 (pyridoxine): helps the body convert food into energy, supports the immune system and aids in the production of red blood cells. Deficiency can cause anemia, convulsions, and skin inflammation.
      • Vitamin B7 (biotin): helps the body convert food into energy and is important for healthy hair and skin. Deficiency is rare but can cause hair loss and skin rashes.
      • Vitamin B9 (folate): helps the body produce red blood cells and is important for pregnant women to support the growth and development of the foetus. Deficiency can cause anemia, birth defects, and miscarriage.
      • Vitamin B12: helps the body produce red blood cells and is important for healthy nerve function. Deficiency can cause anemia, nerve damage, and dementia.
      • Vitamin C: necessary for healthy skin, blood vessels, and the production of collagen. Deficiency can cause scurvy, a condition characterized by fatigue, skin hemorrhages, and joint pain.
      • Vitamin D: necessary for healthy bones, teeth, and immune function. Deficiency can cause rickets, a condition characterized by weak bones and muscle weakness.
      • Vitamin E: helps protect cells from damage and supports healthy skin. Deficiency is rare but can cause nerve damage and muscle weakness.
      • Vitamin K: necessary for blood clotting and healthy bones. Deficiency can cause an increased risk of bleeding and osteoporosis.

      Here is a list of foods that have the essential vitamins for the human body:

      • Vitamin A: sweet potatoes, carrots, leafy green vegetables, eggs, milk, and butter
      • Vitamin B1 (thiamine): whole grains, nuts, seeds, and legumes
      • Vitamin B2 (riboflavin): milk, yogurt, cheese, leafy green vegetables, and mushrooms
      • Vitamin B3 (niacin): chicken, fish, nuts, and whole grains
      • Vitamin B5 (pantothenic acid): mushrooms, avocados, sweet potatoes, and lentils
      • Vitamin B6 (pyridoxine): chicken, fish, potatoes, and leafy green vegetables
      • Vitamin B7 (biotin): eggs, liver, salmon, and avocado
      • Vitamin B9 (folate): leafy green vegetables, citrus fruits, nuts, and legumes
      • Vitamin B12 (cobalamin): meat, fish, dairy, and eggs
      • Vitamin C: citrus fruits, berries, kiwi, papaya, bell peppers, and leafy green vegetables
      • Vitamin D: fatty fish, egg yolks, and mushrooms
      • Vitamin E: nuts, seeds, and leafy green vegetables
      • Vitamin K: leafy green vegetables such as spinach, broccoli, and kale

      It’s important to note that these are mere examples and that many other foods also contain these vitamins. Eating a diet with a variety of fruits, vegetables, whole grains, and lean proteins can help ensure that you’re getting all the essential vitamins your body needs.

      Trace Elements:

      So, what are trace elements or microminerals? And by the way, we only need small amounts of trace minerals. Most people get the amount of minerals they need by eating a wide variety of foods.

      Here is a list of essential trace elements for the human body, along with the potential causes of deficiency and foods that contain them:

      • Iron: necessary to produce red blood cells and the transport of oxygen throughout the body. Deficiency can cause anaemia, fatigue, and weakness. Foods that contain iron include red meat, poultry, seafood, beans, and leafy green vegetables.
      • Zinc: necessary for immune function, wound healing, and the sense of taste and smell. Deficiency can cause delayed wound healing, hair loss, and a loss of appetite. Foods that contain zinc include oysters, beef, pork, chicken, nuts, and legumes.
      • Iodine: necessary to produce thyroid hormones, which regulate metabolism. Deficiency can cause goitre, an enlarged thyroid gland, and decreased mental function. Foods that contain iodine include seafood, dairy products, and iodized salt.
      • Selenium: necessary for the function of the thyroid gland, immune system and to produce antioxidants. Deficiency can cause muscle weakness, fatigue and problems with the heart and blood vessels. Foods that contain selenium include Brazil nuts, tuna, salmon, eggs, and chicken.
      • Copper: necessary to produce red blood cells, nerve function, and the absorption of iron. Deficiency can cause anaemia, osteoporosis, and nerve damage. Foods that contain copper include shellfish, nuts, seeds, and leafy green vegetables.
      • Chromium: necessary for glucose metabolism and insulin function, helps to maintain healthy blood sugar levels. Deficiency can cause glucose intolerance, type 2 diabetes, and cardiovascular disease. Foods that contain chromium include green beans, whole grains, and nuts.
      • Manganese: necessary for the metabolism of carbohydrates, amino acids, and cholesterol, also necessary for healthy bones and the nervous system. Deficiency can cause abnormal bone growth, and problems with the nervous system and the reproductive system. Foods that contain manganese include nuts, whole grains, and leafy green vegetables.
      • Molybdenum: necessary for the metabolism of sulphur-containing amino acids, also necessary for the detoxification of harmful compounds and the production of uric acid. Deficiency is rare but can cause gout and tooth decay. Foods that contain Molybdenum include legumes, whole grains, and leafy greens.

      As with vitamins, it’s important to note that these are just examples and that many other foods also contain these trace elements. Eating a diet with a variety of fruits, vegetables, whole grains, lean proteins, and healthy fats can help ensure that you’re getting all the essential trace elements your body needs.

      7 Major Minerals:

      If you haven’t yet, then watch this short one minute video about “Unlocking the Secrets of Calcium and Magnesium: Your Path to Optimal Health!


      Did you notice the Soldier in your body in this video?

       

      Moving on, these major minerals are used and stored in large quantities in the body and include:
      Calcium:
      • Essential for strong bones and teeth
      • Helps with muscle function and blood clotting.
      • Deficiency can lead to osteoporosis and rickets.
      Chloride:
      • Helps balance fluids in the body.
      • Helps with digestion.
      • Deficiency is rare, as chloride is found in many common foods.
      Magnesium:
      • Helps with muscle and nerve function.
      • Helps with bone health.
      • Deficiency can lead to muscle cramps, fatigue, and weakness.
      Phosphorus:
      • Helps with strong bones and teeth.
      • Helps with cell growth and repair.
      • Deficiency can lead to weak bones and teeth.
      Potassium:
      • Helps with muscle and nerve function.
      • Helps balance fluids in the body.
      • Deficiency can lead to muscle weakness and cramps.
      Sodium:
      • Helps balance fluids in the body.
      • Helps with nerve and muscle function.
      • Deficiency is rare, as sodium is found in many common foods.
      Sulphur:
      • Helps with the formation of connective tissue.
      • Helps with the production of certain amino acids.
      • Deficiency is rare, as sulphur is found in many common foods.

      Note: It’s important to note that excessive intake of any vitamins and minerals can also lead to health problems, therefore it’s important to consult with a doctor to determine the right intake for the individual.

      How do you know what your body needs?

      I’m glad you asked. A quick one minute Quantum Scan can guide you to what you and your family needs, instead of piling up more vitamins, minerals, and other tablets your body may not need.

      Below is an example of a scan done.

      Please note that we always focus on the “Normal Range” reading and the “Actual Measurement Value” and not on the color bar code.

      TraceElementAnalysis_480x480VitaminAnalysis_480x480

      The Quantum magnetic analyzer provides valuable insights into your body’s Collagen needs within each organ. To access this specific information, consider enrolling in Kathy Harding’s “Body Detox Online Course.” This comprehensive course distills 14 years of her detox expertise into an incredibly affordable package. It not only covers Collagen requirements but also delves into essential topics like “Leaky Gut Syndrome” and much more. Don’t miss the chance to enhance your well-being—explore the course today!

      As promised herewith our quick reference list: DOWNLOAD NOW!

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